AIDSinfo: Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection
These updated guidelines address the use of combination antiretroviral therapy (cART) for HIV-infected infants, children, and adolescents (through puberty). Guidance on management of adverse events associated with use of antiretroviral (ARV) drugs in children and a detailed review of information about safety, efficacy, and pharmacokinetics (PK) of ARV agents in children is also included. The Department of Health and Human Services (HHS) Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children (the Panel), a working group of the Office of AIDS Research Advisory Council (OARAC), reviews new data on an ongoing basis and provides regular updates to the guidelines. The guidelines are available on the AIDSinfo website at http://aidsinfo.nih.gov.
The AIDSinfo website also includes separate guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and -infected children,1 for the use of ARV agents in HIV-infected (post–pubertal) adolescents and adults,2 for the use of ARV drugs in pregnant HIV-infected women,3 and for the prevention and treatment of opportunistic infections in HIV-infected adults.4 These guidelines are developed for the United States and may not be applicable in other countries. The World Health Organization (WHO) provides guidelines for resource-limited settings at http://www.who.int/hiv/pub/arv/en.